REVIEW

Clinical and Epidemiological Profile of Patients Diagnosed with Ruptured Cerebral Aneurysm

Perfil Clínico e Epidemiológico de Pacientes Diagnosticados com Ruptura de Aneurisma Cerebral

  • Leandro José Haas (1)    Leandro José Haas (1)
  • Júlia Dumes Hessmann (2)
  • Laura Moll Silva (2)
  • Wallace Mees (2)
  • Bernardo Przysiezny (2)
  • Guilherme Voltolini Staedele (2)
  • Guilherme Wandall (2)
  • Wesley Severino (2)
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Resumo

Introdução: Aneurismas cerebrais são dilatações da parede de uma artéria intracraniana acarretando sintomas quando implicam na compressão de estruturas próximas ou que provocam sangramento. Os aneurismas rotos são considerados emergências médicas, pois sua rutura pode causar sequelas neurológicas graves e levar ao óbito. Portanto, o diagnóstico precoce e o tratamento são necessários para evitar complicações mais graves. Objetivo: Descrever o perfil clínico e epidemiológico de pacientes com rutura de aneurisma cerebral tratados em um serviço de referência em neurocirurgia. Métodos: Estudo observacional retrospetivo baseado em dados do serviço de neurocirurgia endovascular do Hospital Santa Isabel de Blumenau, Santa Catarina, no período de outubro de 2005 a dezembro de 2021. Resultados: Houve 758 aneurismas cerebrais rompidos em pacientes predominantemente do sexo feminino e de idade média de 52,8 anos. Quanto às comorbidades, destacaram-se a hipertensão arterial sistêmica (HAS) (46,9%), seguida pelo tabagismo, dislipidemia e diabetes mellitus. O tipo de aneurisma mais prevalente foi o sacular (95,8%), sendo os pequenos aneurismas (75,5%) os mais encontrados. A maioria dos pacientes apresentava um único aneurisma (77,4%), sendo a artéria comunicante anterior a mais acometida (25,5%). Quanto à gravidade do sangramento, os escores predominantes foram Fisher IV (29,8%) e Hunt-Hess II (44,2%). Quanto ao tratamento endovascular, apenas coils foram utilizadas em 88% dos casos. Em relação à morbimortalidade, o vasoespasmo foi a principal complicação (24,9%), representando 5,2% dos óbitos. Conclusão: Os dados encontrados neste estudo são consistentes com os da literatura, inferindo que a cirurgia endovascular é uma ferramenta eficaz no tratamento de aneurismas rotos.

Palavras-chave

Aneurisma cerebral roto; Endovascular; Coils; Stents

Abstract

Introduction: Brain aneurysms are dilations of the wall of an intracranial artery, causing symptoms when they entail compression of nearby structures or cause bleeding. Ruptured aneurysms are considered medical emergencies, as their rupture can cause severe neurological sequelae and lead to death. Therefore, early diagnosis and treatment are necessary in order to avoid more serious complications. Objective: To describe the clinical and epidemiological profile of patients with ruptured cerebral aneurysm treated in a neurosurgery reference department. Methods: This is a retrospective observational study based on data from the endovascular neurosurgery service at Santa Isabel Hospital, Blumenau, Santa Catarina, from October 2005 to December 2021. Results: There were 758 ruptured cerebral aneurysms in predominantly female patients and mean age of 52.8. As for comorbidities, systemic arterial hypertension (SAH) stood out (46.9%), followed by smoking, dyslipidemia and diabetes mellitus. The most prevalent aneurysm type was saccular (95.8%), and small aneurysms (75.5%) were most often found. Most patients had a single aneurysm (77.4%), and the anterior communicating artery was the most affected one (25.5%). As for the severity of bleeding, the predominant scores were Fisher IV (29.8%) and Hunt-Hess II (44.2%). As for endovascular treatment, only coils were used in 88% of the cases. Regarding morbimortality, vasospasm was the main complication (24.9%), accounting for 5.2% of the deaths. Conclusion: The data found in this study are consistent with those in the literature, inferring that endovascular surgery is an effective tool to treat ruptured aneurysms.

Keywords

Ruptured cerebral aneurysm; Endovascular; Coils; Stents

References

1. Oliva RB. Brain aneurysm and intracranial hemorrhage: literature review about the prognosis. LIPH Science. 2016;3(2):84-97.

2. Bernardo WM, Lima IF, Bernardo LS. Qual a eficácia das micromolas intracerebrais em relação ao procedimento de clipagem cirúrgica nos aneurismas cerebrais rotos? Rev Assoc Med Bras. 2010;56(6):620-1. http://dx.doi.org/10.1590/S0104-42302010000600002. PMid:21271120.

3. Linzey JR, Williamson C, Rajajee V, Sheehan K, Thompson BG, Pandey AS. Twenty-four-hour emergency intervention versus early intervention in aneurysmal subarachnoid hemorrhage. J Neurol. 2018;128(5):1297-303. http://dx.doi.org/10.3171/2017.2.JNS163017. PMid:28731402.

4. Spotti AR, Lima EG, Santos ML, Magalhães ACA. Angiografia pela ressonância magnética nos aneurismas intracranianos: estudo comparativo com a angiografia cerebral. Arq Neuropsiquiatr. 2001;59(2B):384-9. http://dx.doi.org/10.1590/S0004-282X2001000300014. PMid:11460184.

5. Sá AT Jr, Batista MHO, Souza RM, Pereira LS, Siqueira MCP. Estudo restrospectivo: prevalência de aneurismas cerebrais por topografia vascular no Hospital Evangélico Goiano. Rev Bras Neuro Psiq. 2014;18(3):209-23.

6. Oliveira AMP, Paiva WS, Figueiredo EG, Oliveira HA, Teixeira MJ. Fisher revised scale for assessment of prognosis in patients with subarachnoid hemorrhage. Arq Neuropsiquiatr. 2011;69(6):910-3. http://dx.doi.org/10.1590/S0004-282X2011000700012. PMid:22297878.

7. Conrad MD, Pelissou-Guyotat I, Morel C, Madarassy G, Schonauer C, Deruty R. Estudo comparativo entre aneurismas rotos tratadosporcirurgia e por via endovascular. Arq Neuropsiquiatr. 2002;60(1):96-100. http:// dx.doi.org/10.1590/S0004-282X2002000100017. PMid:11965416.

8. Garcia LHC, Ferreira BC. An ABC for decision making. Radiol Bras. 2015;48(2):101-10. http://dx.doi.org/10.1590/0100-3984.2013.1846. PMid:25987751.

9. Choi JY, Choi CH, Ko JK, Lee JI, Huh CW, Lee TH. Feasibility and efficacy of coil embolization for middle cerebral artery aneurysms. Yeungnam Univ J Med. 2019;36(3):208-18. http://dx.doi.org/10.12701/ yujm.2019.00192. PMid:31620635.

10. Cardozo LCC Jr, Barros BP, Holanda MFC. Fatores de risco em pacientes com aneurismas intracranianos atendidos em um hospital de referência de Belém-PA. JBNC. 2011;22(3):95-9.

11. Bonilha L, Marques EL, Carelli EF, et al. Risk factors and outcome in 100 patients with aneurysmal subarachnoid hemorrhage. Arq Neuropsiquiatr. 2001;59(3B):676-80. http://dx.doi.org/10.1590/S0004- 282X2001000500004. PMid:11593263.

12. Rinaldo L, Nesvick CL, Rabinstein AA, Lanzino G. Differences in size between unruptured and ruptured saccular intracranial aneurysms by location. World Neurosurg. 2020;133:e828-34. http://dx.doi. org/10.1016/j.wneu.2019.10.027. PMid:31622680.

13. Beucler N, Haikal C, Hibbert D, et al. Spontaneous acute subdural hematoma: beware of the aneurysm. J Neurosci Rural Pract. 2019;10(3):537- 41. http://dx.doi.org/10.1055/s-0039-1697770. PMid:31595130.

14. Souza MLP, Vieira AC, Azevedo HRC Fo. Escala de Fisher e déficitscognitivos: revisão da literatura. Braz Neurosurg. 2020;39(4):279-83.

15. Hao X, Wei D. The risk factors of shunt-dependent hydrocephalus after subarachnoid space hemorrhage of intracranial aneurysms. Medicine. 2019;98(27):e15970. http://dx.doi.org/10.1097/MD.0000000000015970. PMid:31277089.

16. Ramos F Jr, Marques JAP, Albuquerque LAF, Santos FP, Almeida JPC, Lucena JMP. Surgical management of intracranial aneurysms in the “coiling age”. Braz Neurosurg. 2009;28(1):14-8. http://dx.doi. org/10.1055/s-0038-1625549.

17. Peschillo S, Caporlingua A, Resta MC, et al. Endovascular treatment of large and giant carotid aneurysms with flow-diverter stents alone or in combination with coils: a multicenter experience and long-term follow-up. Oper Neurosurg. 2017;13(4):492-502. http://dx.doi.org/10.1093/ ons/opx032. PMid:28838114.

18. Kallmes DF, Hanel R, Lopes D, et al. International retrospective study of the pipeline embolization device: a multicenter aneurysm treatment study. AJNR Am J Neuroradiol. 2015;36(1):108-15. http:// dx.doi.org/10.3174/ajnr.A4111. PMid:25355814.

19. Yu SCH, Kwok CK, Cheng PW, et al. Intracranial aneurysms: midterm outcome of pipeline embolization device: a prospective study in 143 patients with 178 aneurysms. Radiology. 2012;265(3):893-901. http:// dx.doi.org/10.1148/radiol.12120422. PMid:22996749.

20. Findlay JM, Nisar J, Darsaut T. Cerebral vasospasm: a review. Can J Neurol Sci. 2016;43(1):15-32. http://dx.doi.org/10.1017/cjn.2015.288. PMid:26332908.

21. Ferguson S, MacDonald R. Predictors of cerebral infarction in patients with aneurysmal subarachnoid hemorrhage. Neurosurg. 2007;60(4):658-67. http://dx.doi.org/10.1227/01.NEU.0000255396.23280.31. PMid:17415202.



1 Medical student, Medical School, Regional University of Blumenau, Blumenau, SC, Brazil.

2 MD, Endovascular Neurosurgery, Santa Isabel Hospital, Medical School, Blumenau Regional University, Blumenau, SC, Brazil.

 

Received Feb 5, 2023

Accepted Feb 20, 2023

JBNC  Brazilian Journal of Neurosurgery

  •   ISSN (print version): 0103-5118
  •   e-ISSN (online version): 2446-6786

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