REVIEW
Introdução: Os hemangiopericitomas (HPCs) do Sistema Nervoso Central (SNC) foram descritos primeiramente em 1942 por Stout e Murray como tumores mesenquimais meníngeos que se originam dos pericitos de Zimmermann, ao redor do revestimento endotelial em capilares e vênulas. Metodologia: Os autores apresentam um caso de paciente portador de um hemangiopericitoma meníngeo, operado no Hospital Evangélico de Londrina. Em adendo, foi feita uma revisão da literatura nas bases de dados PubMed, Medline e CAPES, com as palavras-chave: “hemangiopericytoma”; “meningioma”; “Brain Neoplasms”, no intervalo dos últimos seis anos. Foram encontrados 118 artigos, e desses, 47 foram selecionados. Resultados: O HPC possui comportamento agressivo com alto risco de recidiva e metástase. Ressonância magnética não convencional pode ajudar na diferenciação desses tumores como meningioma, sendo os diagnósticos histológico e imuno-histoquímico conclusivos. É recomendada pré-embolização na maioria dos casos, com radioterapia adjuvante para impedir a recidiva do tumor. Discussão: A cirurgia é recomendada em todos os casos com ressecção total da lesão. Ela geralmente é acompanhada por radioterapia adjuvante, na diminuição de recorrência. Conclusão: O diagnóstico é exclusivo por patologia, sendo suscetível a erros. O acompanhamento por anos pós- cirurgia é necessário. A literatura disponível é basicamente composta por relatos de casos, por falta de estudos de acordo com sua raridade.
Introduction: Central Nervous System (CNS) hemangiopericytomas (HPCs) were first described in 1942 by Stout and Murray as meningeal mesenchymal tumors that originate from Zimmermann’s pericytes surrounding the endothelial lining in capillaries and venules. Methodology: The authors present a case of a patient with a meningeal hemangiopericytoma, operated on at the Evangelic Hospital of Londrina. Further, we performed a literature review in the PubMed, Medline, and CAPES databases with the keywords: “hemangiopericytoma”; “meningioma”; “Brain Neoplasms”. A total of 118 papers was found with 47 articles selected, and 71 were excluded. Results: HPC has aggressive behavior with a high risk of recurrence and metastasis. Unconventional MRI can help in differentiating these tumors from meningioma, with a histological and immunohistochemical diagnosis being conclusive. Pre-embolization is recommended in most cases with adjuvant radiotherapy to prevent tumor recurrence. Discussion: Surgery is recommended in all cases with total resection of the lesion. It is usually followed by adjuvant radiotherapy for best results in reducing recurrence and metastasis. Conclusion: Diagnosis is unique by pathology and is susceptible to error. Follow-up for years post-surgery is necessary. The available literature is basically case reports due to its associated rarity.
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(1) Medical student, State University of Londrina, Londrina, PR, Brazil.
(2) MD, MSc. Neurosurgeon, Pontifical Catholic University of Parana, Londrina, PR, Brazil.
(3) Medical student, Pontifical Catholic University of Londrina, Londrina, PR, Brazil.
(4) MD, MR. Medical Residency in Neurosurgery, Evangelic Hospital, Londrina, PR, Brazil.
Received Oct 12, 2021
Corrected Feb 1, 2022
Accepted Mar 27, 2022
