CASE REPORT
A hemorragia subaracnoidea perimesencefálica não aneurismática é um tipo relativamente raro de sangramento subaracnoideo espontâneo, definido pelo acúmulo de sangue em topografias específicas do sistema nervoso central, a saber, cisternas da base (interpeduncular, crural, ambiens e quadrigêmea) podendo se estender para parte posterior da fissura inter-hemisférica anterior e parte basal da fissura sylviana, não associados a sangramento intraventricular franco ou hematoma intraparenquimatoso. É uma condiçãoclínica de curso benigno, mostrando melhor prognóstico que sangramento aneurismático sendo, na maioria das vezes, tratamento conservador. O presente artigo visa descrever o relato de um caso com características de uma hemorragia perimesencefálica na evolução pós-operatória de um adenoma hipofisário não produtor, abordado por via endoscópica assim como revisar epidemiologia, diagnóstico, prognóstico e considerações na literatura sobre a patologia hemorrágica.
Non-aneurysmal perimesencephalic subarachnoid hemorrhage is a relatively rare type of spontaneous subarachnoid bleeding defined by the accumulation of blood in specific topographies of the central nervous system, namely basal cisterns (interpeduncular, crural, ambient and quadrigeminal), which may extend to the posterior part of the fissure. anterior interhemispheric artery and basal part of the sylvian fissure, not associated with frank intraventricular bleeding or intraparenchymal hematoma. It is a clinical condition with benign course, with better prognosis than aneurysmal bleeding and being most often conservative treatment. This article aims to describe a case report with characteristics of a perimesencephalic hemorrhage in the postoperative evolution of a non-producing pituitary adenoma, approached endoscopically, as well as to review epidemiology, diagnosis, prognosis and considerations in the literature on the hemorrhagic pathology.
1. Roman-Filip I, Morosanu V, Bajko Z, Roman-Filip C, Balasa RI. Non-aneurysmal perimesencephalic subarachnoid hemorrhage: a literature review. Diagnostics. 2023;13(6):1195-209. http://dx.doi. org/10.3390/diagnostics13061195. PMid:36980503.
2. Tsubouchi M, Arruda W, Ramina R, et al. Hemorragia subaracnoidea perimesencefálica não aneurismática: apresentação de caso e revisão de literatura. Arq Neuropsiquiatr. 1994;52(1):78-81. http://dx.doi. org/10.1590/S0004-282X1994000100014. PMid:8002813.
3. Purves D, Augustine GJ, Fitzpatrick D. Neuroscience. New York: Sinauer Associates; 2004.
4. Geng B, Wu X, Brackett A, Malhotra A. Meta-analysis of recent literature on utility of follow-up imaging in isolated perimesencephalic hemorrhage. Clin Neurol Neurosurg. 2019;180:111-6. http://dx.doi. org/10.1016/j.clineuro.2019.03.006. PMid:30974309.
5. Mohan M, Islim A, Dulhanty L, Parry-Jones A, Patel H. CT angiogram negative perimesencephalic subarachnoid hemorrhage: is a subsequent DSA necessary? A systematic review. J Neurointerv Surg. 2019;11(12):1216- 21. http://dx.doi.org/10.1136/neurintsurg-2019-015051. PMid:31273072.
6. Maslehaty H, Petridis AK, Barth H, Mehdorn HM. Diagnostic value of magnetic resonance imaging in perimesencephalic and nonperimesencephalic subarachnoid hemorrhage of unknown origin. J Neurosurg. 2011;114(4):1003-7. http://dx.doi. org/10.3171/2010.6.JNS10310. PMid:20672895.
7. Schwartz TH, Solomon RA. Perimesencephalic nonaneurysmal subarachnoid hemorrhage: review of the literature. Neurosurgery. 1996;39(3):433-40. PMid:8875472.
8. Topcuoglu MA, Ogilvy CS, Carter BS, Buonanno FS, Koroshetz WJ, Singhal AB. Subarachnoid hemorrhage without evident cause on initial angiography studies: diagnostic yield of subsequent angiography and other neuroimaging tests. J Neurosurg. 2003;98(6):1235-40. http:// dx.doi.org/10.3171/jns.2003.98.6.1235. PMid:12816270.
9. Flaherty ML, Haverbusch M, Kissela B, et al. Perimesencephalic Subarachnoid Hemorrhage: Incidence, Risk Factors, and Outcome. J Stroke Cerebrovasc Dis. 2005;14(6):267-71. http://dx.doi.org/10.1016/j. jstrokecerebrovasdis.2005.07.004. PMid:16518463.
10. Hirashima Y, Takashima S, Matsumura N, Kurimoto M, Origasa H, Endo S. Right sylvian fissure subarachnoid hemorrhage has electrocardiographic consequences. Stroke. 2001;32(10):2278-81. http://dx.doi.org/10.1161/hs1001.096620. PMid:11588313.
11. van Gijn J, Rinkel GJE. Subarachnoid haemorrhage: diagnosis, causes and management. Brain. 2001;124(2):249-78. http://dx.doi. org/10.1093/brain/124.2.249. PMid:11157554.
12. van Gijn J, van Dongen KJ, Vermeulen M, Hijdra A. Perimesencephalic hemorrhage: a nonaneurysmal and benign form of subarachnoid hemorrhage. Neurology. 1985;35(4):493-7. http://dx.doi.org/10.1212/ WNL.35.4.493. PMid:3982634.
13. van der Schaaf IC, Velthuis BK, Gouw A, Rinkel GJE. Venous drainage in perimesencephalic hemorrhage. Stroke. 2004;35(7):1614-8. http:// dx.doi.org/10.1161/01.STR.0000131657.08655.ce. PMid:15166390.
14. Roman-Filip CC, Stîngaciu AR, Catană MG, et al. Atypical posterior circulation strokes: a case-based review of rare anatomical variations involved. Rom J Morphol Embryol. 2021;62(1):289-93. http://dx.doi. org/10.47162/RJME.62.1.31. PMid:34609434.
15. Kapadia A, Schweizer TA, Spears J, Cusimano M, Macdonald RL. Nonaneurysmal perimesencephalic subarachnoid hemorrhage: diagnosis, pathophysiology, clinical characteristics, and long-term outcome. World Neurosurg. 2014;82(6):1131-43. http://dx.doi.org/10.1016/j. wneu.2014.07.006. PMid:25003696.
16. Shad A, Rourke TJ, Hamidian Jahromi A, Green AL. Straight sinus stenosis as a proposed cause of perimesencephalic non-aneurysmal haemorrhage. J Clin Neurosci. 2008;15(7):839-41. http://dx.doi. org/10.1016/j.jocn.2007.03.024. PMid:18406143.
17. Mathews MS, Brown D, Brant-Zawadzki M. Perimesencephalic nonaneurysmal hemorrhage associated with vein of Galen stenosis. Neurology. 2008;70(24 Pt 2):2410-1. http://dx.doi.org/10.1212/01. wnl.0000314688.26295.03. PMid:18541874.
18. Şahin S, Delen E, Korfali E. Perimesencephalic subarachnoid hemorrhage: etiologies, risk factors, and necessity of the second angiogram. Asian J Neurosurg. 2016;11(1):50-3. http://dx.doi. org/10.4103/1793-5482.165793. PMid:26889280.
19. Sailer AMH, Wagemans BAJM, Nelemans PJ, de Graaf R, van Zwam WH. Diagnosing intracranial aneurysms with MR angiography: systematic review and meta-analysis. Stroke. 2014;45(1):119-26. http:// dx.doi.org/10.1161/STROKEAHA.113.003133. PMid:24326447.
20. Potter CA, Fink KR, Ginn AL, Haynor DR. Perimesencephalic hemorrhage: yield of single versus multiple DSA examinations: a single-center study and meta-analysis. Radiology. 2016;281(3):858-64. http:// dx.doi.org/10.1148/radiol.2016152402. PMid:27232640.
21. Heit JJ, Pastena GT, Nogueira RG, et al. Cerebral angiography for evaluation of patients with CT angiogram-negative subarachnoid hemorrhage: an 11-year experience. AJNR Am J Neuroradiol. 2016;37(2):297-304. http://dx.doi.org/10.3174/ajnr.A4503. PMid:26338924.
22. Kalra VB, Wu X, Forman HP, Malhotra A. Cost-effectiveness of angiographic imaging in isolated perimesencephalic subarachnoid hemorrhage. Stroke. 2014;45(12):3576-82. http://dx.doi.org/10.1161/ STROKEAHA.114.006679. PMid:25336513.
23. Moreira ES. Diencéfalo I: filogênese, ontogênese, macroscopia. Epitálamo, tálamo, subtálamo, retina, as vias visuais e suas principais lesões. In: Moreira ES, editor. Coleção monografias neuroanatômicas morfo-funcionais. Volta Redonda: UNIFOA; 2017. p. 179.
24. Hsu W, Pradilla G, Garonzik IM, Conway JE. Pretruncal nonaneurysmal subarachnoid hemorrhage causing basilar artery vasospasm. Neurocrit Care. 2010;13(2):256-60. http://dx.doi. org/10.1007/s12028-010-9354-1. PMid:20422468.
25. Schievink WI, Wijdicks EF, Spetzler RF. Diffuse vasospasm after pretruncal nonaneurysmal subarachnoid hemorrhage. AJNR Am J Neuroradiol. 2000;21(3):521-3. PMid:10730645.
26. Prat D, Goren O, Bruk B, Bakon M, Hadani M, Harnof S. Description of the vasospasm phenomena following perimesencephalic nonaneurysmal subarachnoid hemorrhage. BioMed Res Int. 2013;2013:371063. http:// dx.doi.org/10.1155/2013/371063. PMid:24455690.
27. Merkel H, Lindner D, Gaber K, et al. Standardized classification of cerebral vasospasm after subarachnoid hemorrhage by digital subtraction angiography. J Clin Med. 2022;11(7):2011. http://dx.doi.org/10.3390/ jcm11072011. PMid:35407619.
28. Nesvick CL, Oushy S, Rinaldo L, Wijdicks EF, Lanzino G, Rabinstein AA. Clinical complications and outcomes of angiographically negative subarachnoid hemorrhage. Neurology. 2019;92(20):e2385 -94. http:// dx.doi.org/10.1212/WNL.0000000000007501. PMid:30996058.
29. Connolly ES Jr, Rabinstein AA, Carhuapoma JR, et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline.
1 MD, MR, Neurosurgery Service, São Marcos Hospital, Associação Piauiense de Combate ao Câncer – APCC, Teresina, PI, Brazil.
2 MD, MR, Neurosurgery Department, Getúlio Vargas Hospital – HGV, Teresina, PI, Brazil.
3 MD, Otorhinolaryngology Department, Getúlio Vargas Hospital – HGV, Teresina, PI, Brazil.
4 MD, PhD, Neurosurgeon, Adjunct professor, School of Medical Sciences – FACIME, State University of Piauí – UESPI, Teresina, PI, Brazil.
5 MD, MSc., Neurosurgeon, Federal University of Piaui, Teresina, PI, Brazil.
6 MD, MSc., Neurosurgeon, Getulio Vargas Hospital – HGV, Teresina, PI, Brazil.
Received Sep 28, 2023
Accepted Oct 3, 2023