Synchronous Glioblastoma and Grade 1 Angiomatoid Meningioma: case report and literature review

Glioblastoma e Meningioma Angiomatoide Grau 1 Sincrônicos: relato de caso e revisão da literatura

• Rafael Harter Tomaszeski
• Natily Haskel
• Luiza Ribeiro
• Eduardo Cambruzzi
• Marcos Dalsin
• Gerson Evandro Perondi
• Samir Cezimbra dos Santos
• Felipe Lourezon Schiavo

• https://doi.org/10.22290/jbnc.2025.360317
• J Bras Neurocirur 36 (3):392-398, 2025

Resumo

A coexistência de glioblastoma (GBM) e meningioma é um achado raro. O glioblastoma é o tumor cerebral primário mais agressivo em adultos, enquanto o meningioma, geralmente benigno, apresenta crescimento lento. Este estudo apresenta o caso de uma paciente de 69 anos diagnosticada com ambas as neoplasias, confirmadas por análise histopatológica e imuno-histoquímica após ressecção cirúrgica. A literatura sugere diversas hipóteses para essa ocorrência, incluindo predisposição genética, influências microambientais e possíveis mecanismos compartilhados de sinalização celular. Apesar das diferentes origens e prognósticos, a presença simultânea desses tumores representa um desafio diagnóstico e terapêutico.

Palavras-chave

Glioblastoma, meningioma, tumor cerebral:

Abstract

The coexistence of glioblastoma (GBM) and meningioma is a rare finding. The glioblastoma is the most aggressive primary brain tumor in adults, while meningioma, which is usually benign, is slow growing. This study presents the case of a 69-year-old patient diagnosed with both neoplasms, confirmed by histopathological and immunohistochemical analysis after surgical resection. The literature suggests several hypotheses for this occurrence, including genetic predisposition, microenvironmental influences and possible shared cellular signaling mechanisms. Despite the different origins and prognoses, the simultaneous presence of these tumors represents a diagnostic and therapeutic challenge.

Keywords

Glioblastoma; Meningioma; Brain tumors

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1Serviço de Neurocirurgia do Hospital Criança Conceição, Grupo Hospitalar Conceição, Porto Alegre, RS, Brazil.

2Universidade de Caxias do Sul, Caxias do Sul, RS, Brazil.

 

Received May 13, 2025

Accepted Jun 4, 2025